Publications

2021 Show content

Ziegler AC, Müller T, Gräler MH. (2021) Sphingosine 1-phosphate in sepsis and beyond: Its role in disease tolerance and host defense and the impact of carrier molecules.
Cell Signal. 2021 Feb;78:109849. doi: 10.1016/j.cellsig.2020.109849 → CRA4

Laiqi T, Marx C, Hudalla H, Haas F, Große S, Wang Z, Heller R, Bauer M, Wetzker R, Bauer R. (2021) The Role of Pathogen Dose and PI3Kγ in Immunometabolic Reprogramming of Microglia for Innate Immune Memory. Int J of Mol Sci 2021, 22(5), 2578 → CRA1 / CRA3

2020 Show content

Spengler K, Kryeziu N, Große S, Mosig AS, Heller R.( 2020) VEGF Triggers Transient Induction of Autophagy in Endothelial Cells via AMPKα1.  Cells. Mar 11 2020;9(3):687. doi: 10.3390/cells9030687. PMID: 32168879; PMCID: PMC7140637. → CRA1

Jeya Paul J, Weigel C, Müller T, Heller R, Spiegel S, Gräler MH. (2020)
Inflammatory Conditions Disrupt Constitutive Endothelial Cell Barrier Stabilization by Alleviating Autonomous Secretion of Sphingosine 1-Phosphate. Cells. 2020 Apr 10;9(4):928. doi: 10.3390/cells9040928. PMID: 32290092; PMCID: PMC7226983. → CRA1 / CRA4

Sharifi S, da Costa HFR, Bierhoff H. (2020) The circuitry between ribosome biogenesis and translation in stem cell function and ageing.
Mech Ageing Dev. 2020 Jul;189:111282. → CRA1

Weigel C, Hüttner S, Ludwig K, Krieg N, Hofmann S†, Schröder NH, Robbe L, Kluge S, Nierhaus A, Winkler MS, Rubio I, von Maltzahn J , Spiegel S, Gräler MH. (2020) S1P lyase inhibition protects against sepsis by promoting disease tolerance via the S1P/S1PR3 axis.
EBioMedicine  Volume 58, August 2020, 102898. → CRA4

Ludwig K, Husain RA, Rubio I. (2020) mTORC1 Is Not Principally Involved in the Induction of Human Endotoxin Tolerance.
Front Immunol. 2020 Aug 7;11:1515. → CRA4

Lajqi T, Stojiljkovic MR, Williams DL, Hudalla H, Bauer M, Witte OW, Wetzker R, Bauer R, Schmeer C. (2020) Memory-Like Responses of Brain Microglia Are Controlled by Developmental State and Pathogen Dose.
Front. Immunol., 25 September 2020 → CRA3

Lang GP, Ndongson-Dongmo B, Lajqi T, Brodhun M, Han Y, Wetzker R, Frasch MG, Bauer R. (2020) Impact of ambient temperature on inflammation-induced encephalopathy in endotoxemic mice-role of phosphoinositide 3-kinase gamma.
J Neuroinflammation. 2020 Oct 7;17(1):292. doi: 10.1186/s12974-020-01954-7. → CRA3

Thuy AV, Jeya Paul J, Weigel C, Ziegler AC, Guntinas-Lichius O, Gräler MH. (2020) Validation of a monoclonal antibody directed against the human sphingosine 1-phosphate receptor type 1.
J Immunol Methods. 2020 Dec 30:112953. doi: 10.1016/j.jim.2020.112953. → CRA4

Coburger I, Yang K, Bernert A, Wiesel E, Swain SM, Sahoo N, Schönherr R, Hoshi T, Heinemann SH. (2020) Impact of intracellular hemin on N-type inactivation of voltage-gated K+ channels.
Pflugers Arch – European Journal of Physiology 472 551–560 PMID: 32388729. DOI: 10.1007/s00424-020-02386-1 → CRA3

Espada L, Dakhovnik A, Chaudhari P, Martirosyan A, Miek L, Poliezhaieva T, Schaub Y, Nair A, Döring N, Rahnis N, Werz O, Koeberle A, Kirkpatrick J, Ori A, Ermolaeva MA. (2020) Loss of metabolic plasticity underlies metformin toxicity in aged Caenorhabditis elegans.
Nat Metab. 2020 Nov;2(11):1316-1331 → CRA4

2019 Show content

Stojiljkovic MR, Ain Q, Bondeva T, Heller R, Schmeer C, Witte OW. (2019) Phenotypic and functional differences between senescent and aged murine microglia.
Neurobiol Aging. 2019 Feb;74:56-69. → CRA1 / CRA3

Ndongson-Dongmo B, Lang GP, Mece O, Hechaichi N, Lajqi T, Hoyer D, Brodhun M, Heller R, Wetzker R, Franz M, Levy FO, Bauer R. (2019) Reduced ambient temperature exacerbates SIRS-induced cardiac autonomic dysregulation and myocardial dysfunction in mice.
Basic Res Cardiol. 2019 Apr 23;114(3):26. → CRA1 / CRA3

Bocker HT, Heinrich T, Liebmann L, Hennings JC, Seemann E, Gerth M, Jakovčevski I, Preobraschenski J, Kessels MM, Westermann M, Isbrandt D, Jahn R, Qualmann B, Hübner CA. (2019) The Na+/H+ Exchanger Nhe1 Modulates Network Excitability via GABA Release. Cereb Cortex Sep 13;29(10):4263-4276. → CRA2

Wolf D, Hofbrucker-MacKenzie SA, Izadi M, Seemann E, Steiniger F, Schwintzer L, Koch D, Kessels MM§, Qualmann B§. (2019) Ankyrin repeat-containing N-Ank proteins shape cellular membranes. Nat Cell Biol. 2019 Oct;21(10):1191-1205. → CRA2
§ shared corresponding authorship

Kamaletdinova K, Fanaei-Kahrani Z, Wang  ZQ. (2019) The Enigmatic Function of PARP1: From PARylation Activity to PAR Readers. Cells Dec 12;8(12):1625. → CRA4

Yang, K, Coburger I, Langner J, Peter N, Hoshi T, Schönherr R, Heinemann SH. (2019) Modulation of K+ channel N-type inactivation by sulfhydration through hydrogen sulfide and polysulfides.
Pflugers Arch – European Journal of Physiology 471 557–571. PMID: 30415410 → CRA3

Laiqi T, Lang GP, Haas F, Williams LD, Hudalla H, Bauer M, Groth M, Wetzker R, Bauer R. (2019) Memory-Like Inflammatory Responses of Microglia to Rising Doses of LPS: Key Role of PI3Kγ.
Front Immunol. 2019, 10: 2492 → CRA3

2018 Show content

Glatzel DK, Koeberle A, Pein H, Loeser K, Stark A, Keksel N, Werz O, Müller R, Bischoff I, Fürst R (2018) Acetyl-CoA carboxylase 1 regulates endothelial cell migration by shifting the phospholipid composition J Lipid Res 59: 298-311→ CRA1 / CRA3

Izadi M, Schlobinski D, Lahr M, Schwintzer L, Qualmann B§, Kessels MM§. (2018) Cobl-like promotes actin filament formation and dendritic branching using only a single WH2 domain.
J Cell Biol. 2018 Jan 2;217(1):211-230. → CRA2
§shared corresponding authorship

Hou W, Nemitz S, Schopper S, Nielsen ML, Kessels MM§, Qualmann B§. Arginine Methylation by PRMT2 Controls the Functions of the Actin Nucleator Cobl. Dev Cell. 2018 Apr 23;45(2):262-275.e8. → CRA2
§shared corresponding authorship

Marx C, Marx-Blümel L, Thierbach R, Poburski D, Becker S, Wittig S, Lehmann R, Slevogt H, Heinzel T, Wang ZQ, Beck JF, Sonnemann J (2018) The sirtuin 1/2 inhibitor tenovin-1 induces a nonlinear apoptosis-inducing factor-dependent cell death in a p53 null Ewing's sarcoma cell line. Investigational New Drugs, Jun;36(3):396-406. → CRA1 / CRA4

Balakrishnan P, Liebe T, Amro E, Dhaka L, Heinzel T, Heller R (2018) Metabolic stress - signaling and metabolic adaptation.
In: The Science of Hormesis in Health and Longevity, (S. I. S. Rattan, M. Kyriazi, Ed.) Academic Press 139-148CRA1

Mägdefrau AS, Ludwig K, Weigel C, Köse N, Guerra GM, Dakhovnik A, Kosan C (2018)
DNA-Damage-Induced Hormetic Responses.
In: The Science of Hormesis in Health and Longevity, (S. I. S. Rattan, M. Kyriazi, Ed.) Academic Press 149-159CRA4

Jentho E, Lajqi T, Yang K, Winkler R, Stojiljkovic M, Wetzker R, Bauer M (2018)
Pathogen-induced hormetic responses
in: The Science of Hormesis in Health and Longevity (S. I. S. Rattan, M. Kyriazi, Ed.) Academic Press 161-170 → CRA3

Hofbrucker-MacKenzie SA, Sivaprakasam I, Ji Y, Kessels MM, Qualmann B (2018)
Neuronal Stress and Its Hormetic Aspects.
in: The Science of Hormesis in Health and Longevity (S. I. S. Rattan, M. Kyriazi, Ed.) Academic Press 171-180 → CRA2

Spengler K, Große S, Kryeziu N, Knierim A, Heller R. (2018) Studying the Role of AMPK in Angiogenesis. Methods Mol Biol. 2018;1732:519-537. → CRA1

Izadi M, Hou W, Qualmann B, Kessels MM. (2018) Direct effects of Ca2+/calmodulin on actin filament formation. Biochem Biophys Res Commun. 2018 Nov 25;506(2):355-360. doi: 10.1016/j.bbrc.2018.07.159. → CRA2

2017 Show content

Schneble N, Muller J, Kliche S, Bauer R, Wetzker R, Bohmer FD, Wang ZQ, Muller JP (2017) The protein-tyrosine phosphatase DEP-1 promotes migration and phagocytic activity of microglial cells in part through negative regulation of fyn tyrosine kinase. Glia 65:416-428. → CRA3 / CRA4

Pein H, Koeberle SC, Voelkel M, Schneider F, Rossi A, Thürmer M, Löser K, Sautebin L, Morrison H, Werz O, Koeberle A (2017) Vitamin A regulates Akt signaling through the phospholipid fatty acid composition. FASEB J 31: 4566-4577 → CRA1 / CRA3

Weis S, Rubio I, Ludwig K, Weigel C, Jentho E (2017) Hormesis and Defense of Infectious Disease. Int J Mol Sci 18(6). → CRA4

Schäfer C, Göder A, Beyer M, Kiweler N, Mahendrarajah N, Rauch A, Nikolova T, Stojanovic N, Wieczorek M, Reich T, Tomicic MT, Linnebacher M, Sonnemann J, Dietrich S, Sellmer A, Mahboobi S, Heinzel T, Schneider G, and Krämer OH (2017) Class I histone deacetylases regulate p53/NF-kB crosstalk in cancer cells. Cellular Signalling 29, 218-225. → CRA1

Schuhwerk H, Atteya R, Siniuk K, Wang ZQ (2017) PARPing for Balance in the Homeostasis of poly(ADP-ribosyl)ation. Semin Cell Dev Biol Mar;63:81-91. → CRA4

Zibrova D, Vandermoere F, Göransson O, Peggie M, Mariño KV, Knierim A, Spengler K, Weigert C, Viollet B, Morrice NA, Sakamoto K, Heller R. (2017) GFAT1 phosphorylation by AMPK promotes VEGF-induced angiogenesis
Biochem J. 2017 Mar 7;474(6):983-1001. → CRA1

Frahm C, Srivastava A, Schmidt S, Mueller J, Groth M, Guenther M, Ji Y, Priebe S, Platzer M, Witte OW. (2017)  Transcriptional profiling reveals protective mechanisms in brains of long-lived mice. Neurobiol Aging. 2017 Apr;52:23-31. → CRA2

Seemann E, Sun M, Krueger S, Tröger J, Hou W, Haag N, Schüler S, Westermann M, Huebner CA, Romeike B, Kessels MM§, Qualmann B§. (2017) Deciphering caveolar functions by syndapin III KO-mediated impairment of caveolar invagination. Elife. 2017 Dec 5;6:e29854. doi: 10.7554/eLife.29854. → CRA2
§shared corresponding authorship

2016 Show content

Kresinsky A, Schneble N, Schmidt C, Frister A, Bauer R,Wetzker R, Muller JP (2016) Phagocytosis of bone marrow derived macrophages is controlled by phosphoinositide 3-kinase gamma. Immunol Lett 180:9-16. → CRA3

Hemdan NY, Weigel C, Reimann CM, Gräler MH (2016) Modulating sphingosine 1-phosphate signaling with DOP or FTY720 alleviates vascular and immune defects in mouse sepsis. European Journal of Immunology 46, 2767-2777 → CRA4

Schink M, Leipold E, Schirmeyer J, Schönherr R, Hoshi T, Heinemann SH (2016) Reactive species modify NaV1.8 channels and affect action potentials in murine dorsal root ganglia neurons. Pflugers Arch EJP Jan;468(1):99-110. → CRA3

Koeberle A, Löser K, Thürmer M (2016) Stearoyl-CoA desaturase-1 and adaptive stress signaling. BBA-MOL CELL BIOL L 1861: 1719-1726. → CRA1

Gottlieb-Abraham E, Gutman O, Pai GM, Rubio I, Henis YI. The residue at position 5 of the N-terminal region of Src and Fyn modulates their myristoylation, palmitoylation, and membrane interactions. Mol Biol Cell. 2016;27(24):3926-36. → CRA4

Pai GM, Zielinski A, Koalick D, Ludwig K, Wang Z-Q, Borgmann K, Pospiech H, Rubio I. (2016) TSC loss distorts DNA replication programme and sensitises cells to genotoxic stress. Oncotarget 7(51):85365-80 → CRA4

Wales P, Schuberth CE, Aufschnaiter R, Fels J, García-Aguilar I, Janning A, Dlugos CP, Schäfer-Herte M, Klingner C, Wälte M, Kuhlmann J, Menis E, Hockaday Kang L, Maier KC, Hou W, Russo A, Higgs HN, Pavenstädt H, Vogl T, Roth J, Qualmann B, Kessels MM, Martin DE, Mulder B, Wedlich-Söldner R. (2016) Calcium-mediated actin reset (CaAR) mediates acute cell adaptations. Elife. 2016 Dec 6;5:e19850. doi: 10.7554/eLife.19850. → CRA2

2015 Show content

Khaminets A*, Heinrich T*, Mari M, Grumati P, Huebner AK, Akutsu M, Liebmann L, Stolz A, Nietzsche S, Koch N, Mauthe M, Katona I, Qualmann B, Weis J, Reggiori F, Kurth I§, Hübner CA§, Dikic I§ (2015) Regulation of endoplasmic reticulum turnover by selective autophagy. Nature 522: 354-358.    *equal contribution and §shared senior authorship → CRA2

Ndongson-Dongmo B, Heller R, Hoyer D, Brodhun M, Bauer M, Winning J, Hirsch E, Wetzker R, Schlattmann P, Bauer R (2015) Phosphoinositide 3-kinase gamma controls inflammation-induced myocardial depression via sequential cAMP- and iNOS- signaling. Cardiovasc Res Nov 1;108(2):243-53. → CRA1 / CRA3

Reimann CM, Thuy AV, Weigel C, Gräler MH (2015) Sphingosine 1-phosphate (S1P) in cancer immunity and development. Transl Cancer Res doi: 10.3978/j.issn.2218-676X.2015.09.01 → CRA4

Wallert M, Schmölz L, Koeberle A, Krauth V, Glei M, Galli F, Werz O, Birringer M, Lorkowski S (2015) α-Tocopherol long-chain metabolite α-13'-COOH affects the inflammatory response of lipopolysaccharide-activated murine RAW264.7 macrophages. Mol Nutr Food Res 59: 1524-1534. → CRA1 / CRA3

Hou W, Izadi M, Nemitz S, Haag N, Kessels MM, Qualmann B (2015) The actin nucleator Cobl is controlled by calcium and calmodulin. PLoS Biol 13: e1002233. → CRA2

Stark H, Fichtner M, König R, Lorkowski S, Schuster S (2015). Causes of upregulation of glycolysis in lymphocytes upon stimulation. A comparison with other cell types. Biochimie Nov;118:185-94. → CRA1 / CRA3

Schuster S, Boley D, Möller P, Stark H, Kaleta C (2015) Mathematical models for explaining the Warburg effect: A review focussed on ATP and biomass production. Biochem Soc Trans ec;43(6):1187-94. doi: 10.1016/j.biochi.2015.09.017. → CRA1

Schuster S, Boley D, Möller P, Kaleta C (2015a) A minimal model for explaining the higher ATP production in the Warburg effect. Proceed. GCB 2015, PeerJ PrePrints 3: e1609. → CRA1

Zobel T, Brinkmann K, Koch N, Schneider K, Seemann E, Fleige A, Qualmann B, Kessels MM, Bogdan S. (2015) Cooperative functions of the two F-BAR proteins Cip4 and Nostrin in the regulation of E-cadherin in epithelial morphogenesis. J Cell Sci. 2015 Feb 1;128(3):499-515. doi: 10.1242/jcs.155929. → CRA2

2014 Show content

Frister A, Schmidt C, Schneble N, Brodhun M, Gonnert FA, Bauer M, Hirsch E, Müller JP, Wetzker R, Bauer R (2014) Phosphoinositide 3-kinase γ affects LPS-induced disturbance of blood-brain barrier via lipid kinase-independent control of cAMP in microglial cells. Neuromol Med 16: 704-713 → CRA3

Rauch A, Hennig D, Schäfer C, Wirth M, Marx C, Heinzel T, Schneider G, Krämer OH (2014) Survivin and YM155: How faithful is the liaison? Biochim Biophys Acta Rev Canc 1845: 202-220. → CRA1

Schneider K, Seemann E, Liebmann L, Ahuja R, Koch D, Westermann M, Hübner CA, Kessels MM§, Qualmann B§ (2014). ProSAP1 and membrane nanodomain-associated syndapin I promote postsynapse formation and function. J Cell Biol 205: 197-215. 
§shared senior authorship → CRA2

Baple E*, Maroofian R*, Chioza BA*, Izadi M*, Cross HE, Al-Turki S, Barwick K, Wagner K, Coblentz R, Zainy T, Patton MA, Qualmann B, Hurles M, Kessels MM, Crosby AH. (2014) Mutations in KPTN cause macrocephaly, neurodevelopmental delay, and seizures. Am J Hum Genet 94(1):87-94.       *shared authorships → CRA2

Weimer S, Priebs J, Kuhlow D, Groth M, Priebe S, Mansfeld J, Merry TL, Dubuis S, Laube B, Pfeiffer AF, Schulz TJ, Guthke R, Platzer M, Zamboni N, Zarse K, Ristow M (2014) D-Glucosamine supplementation extends lifespan of nematodes and of aging mice. Nature Communications 5: 3563. → CRA1

Segref A, Kevei E, Pokrzywa W, Schmeisser K, Mansfeld J, Livnat-Levanon N, Ensenauer R, Glickman MH, Ristow M, Hoppe T (2014) Pathogenesis of Human Mitochondrial Diseases Is Modulated by Reduced Activity of the ubiquitin/proteasome System. Cell Metabolism 19: 642-52. → CRA1

Madishetti S, Schneble N, König C, Hirsch E, Schulz S, Müller JP, Wetzker R (2014) PI3Ky integrates cAMP and Akt signalling of the μ-opioid receptor. Br J Pharmacol 171: 3328-3337. → CRA3

Schmidt C, Schneble N, Wetzker R (2014) The fifth dimension of innate immunity. J Cell Commun Signal 8: 363-367. → CRA3

Schumacher L*, Urbach A*, Lutzenburg M, Bidmon HJ, Witte OW (2014) Bihemispheric ischemic tolerance induced by a unilateral focal cortical lesion. Brain Res 1570: 54-60.  *shared first authorship → CRA3

2013 Show content

Schmidt C, Schneble N, Muller JP, Bauer R, Perino A, Marone R, Rybalkin SD, Wymann MP, Hirsch E, Wetzker R (2013) Phosphoinositide 3-kinase gamma mediates microglial phagocytosis via lipid kinase-independent control of cAMP. Neuroscience 233:44-53. → CRA3

Ermolaeva MA, Segref A, Dakhovnik A, Ou HL, Schneider JI, Utermöhlen O, Hoppe T, Schumacher B. (2013) DNA damage in germ cells induces an innate immune response that triggers systemic stress resistance. Nature 501: 416-420. → CRA4

Leipold E, Liebmann L, Korenke GC, Heinrich T, Giesselmann S, Baets J, Ebbinghaus M, Goral RO, Stödberg T, Hennings JC, Bergmann M, Altmüller J, Thiele H, Wetzel A, Nürnberg P, Timmerman V, De Jonghe P, Blum R, Schaible HG, Weis J, Heinemann SH, Hübner CA, Kurth I (2013) A de novo gain-of-function mutation in SCN11A causes loss of pain perception. Nature Genet 45: 1399-1404. → CRA2 / CRA3

Schulz A, Baader SL, Niwa-Kawakita M, Jung MJ, Bauer R, Garcia C, Zoch A, Schacke S, Hagel C, Mautner VF, Hanemann CO, Dun XP, Parkinson DB, Weis J, Schröder JM, Gutmann DH, Giovannini M, Morrison H (2013) Merlin isoform 2 in neurofibromatosis type 2-associated polyneuropathy. Nat Neurosci 16: 426-433. → CRA2 / CRA3

Geißler KJ, Jung MJ, Riecken LB, Sperka T, Cui Y, Schacke S, Merkel U, Markwart R, Rubio I, Than ME, Than-Breithaupt C, Peuker S, Seifert R, Kaupp UB, Herrlich P, Morrison H (2013) Regulation of Son of sevenless by the membrane-actin linker protein ezrin. Proc Natl Acad Sci USA 110: 20587-20592. → CRA2 / CRA4

Nolze A, Schneider J, Keil R, Lederer M, Huttelmaier S, Kessels MM, Qualmann B, Hatzfeld M (2013) FMRP regulates actin filament organization via the armadillo protein p0071. RNA 19: 1483-1496. → CRA2

Schmeisser K*, Mansfeld J*, Kuhlow D, Weimer S, Priebe S, Heiland I, Birringer M, Groth M, Segref A, Kanfi Y, Price NL, Schmeisser S, Schuster S, Pfeiffer AFH, Guthke R, Platzer M, Hoppe T, Cohen HY, Zarse K, Sinclair DA, Ristow M (2013) Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide. Nature Chemical Biology 9: 693-700 - *shared first authorship → CRA1

2012 Show content

Ginter T, Bier C, Knauer SK, Sughra K, Hildebrand D, Münz T, Liebe T, Heller R, Henke A, Stauber RH, Reichardt W, Schmid JA, Kubatzky KF, Heinzel T, Krämer OH (2012) Histone deacetylase inhibitors block IFNγ-induced STAT1 phosphorylation. Cell Signal 24: 1453-1460. → CRA1

Wetzker R, Rubio I (2012) Hormetic signalling patterns. Dose Response 10: 83-90 → CRA3 / CRA4

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