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Publications

Bauer, Michael

Press AT, Traeger A, Pietsch C, Mosig A, Wagner M, Jbeily N, Koch N, Gottschaldt M, Ermolayev V, Beziere N, Popp J, Kessels MM, Qualmann B, Clemens MG, Ntziachristos V, Schubert US, Bauer M (2014) Cell type-specific delivery of short interfering RNAs by dye-functionalized theranostic nanoparticles. Nature Commun 5:5565.

Weber M, Lambeck S, Ding N, Henken S, Kohl M, Deigner HP, Enot DP, Igwe EI, Frappart L, Kiehntopf M, Claus RA, Kamradt T, Weih D, Vodovotz Y, Briles DE, Ogunniyi AD, Paton JC, Maus UA, Bauer M (2012) Hepatic induction of cholesterol biosynthesis reflects a remote adaptive response to pneumococcal pneumonia. FASEB J 26:2424-36.

Recknagel P, Gonnert FA, Westermann M, Lambeck S, Lupp A, Rudiger A, Dyson A, Carré JE, Kortgen A, Krafft C, Popp J, Sponholz C, Fuhrmann V, Hilger I, Claus RA, Riedemann NC, Wetzker R, Singer M, Trauner M, Bauer M (2012) Liver dysfunction and phosphatidylinositol-3-kinase signalling in early sepsis: experimental studies in rodent models of peritonitis. PLoS Med 9: e1001338.


Bauer, Reinhard

Schmidt C, Schneble N, Muller JP, Bauer R, Perino A, Marone R, Rybalkin SD, Wymann MP, Hirsch E, Wetzker R (2013) Phosphoinositide 3-kinase gamma mediates microglial phagocytosis via lipid kinase-independent control of cAMP. Neuroscience 233:44-53.

Frister A, Schmidt C, Schneble N, Brodhun M, Gonnert FA, Bauer M, Hirsch E, Müller JP, Wetzker R, Bauer R (2014) Phosphoinositide 3-kinase γ affects LPS-induced disturbance of blood-brain barrier via lipid kinase-independent control of cAMP in microglial cells. Neuromol Med 16: 704-713.

Ndongson-Dongmo B, Heller R, Hoyer D, Brodhun M, Bauer M, Winning J, Hirsch E, Wetzker R, Schlattmann P, Bauer R (2015) Phosphoinositide 3-kinase gamma controls inflammation-induced myocardial depression via sequential cAMP- and iNOS- signaling. Cardiovasc Res [Epub ahead of print]

Kresinsky A, Schneble N, Schmidt C, Frister A, Bauer R,Wetzker R, Muller JP (2016) Phagocytosis of bone marrow derived macrophages is controlled by phosphoinositide 3-kinase gamma. Immunol Lett 180:9-16. 

Schneble N, Muller J, Kliche S, Bauer R, Wetzker R, Bohmer FD, Wang ZQ, Muller JP (2017) The protein-tyrosine phosphatase DEP-1 promotes migration and phagocytic activity of microglial cells in part through negative regulation of fyn tyrosine kinase. Glia 65:416-428.

 

Bruns, Tony

Zimmermann HW, Bruns T, Weston CJ, Curbishley SM, Liaskou E, Li KK, Resheq YJ, Badenhorst PW, Adams DH (2105) Bidirectional Transendothelial Migration Of Monocytes Across Hepatic Sinusoidal Endothelium Shapes Monocyte Differentiation And Regulates The Balance Between Immunity And Tolerance In Liver. Hepatology. Accepted on 08/09/2015

Bruns T, Zimmermann HW, Pachnio A, Li K-K, Trivedi PJ, Reynolds G, Hubscher S, Stamataki Z, Badenhorst PW, Weston CJ, Moss PA & Adams DH (2015) CMV infection of human sinusoidal endothelium regulates hepatic T cell recruitment and activation. J. Hepatol 63: 38-49.

Reuken PA, Kussmann A, Kiehntopf M, Budde U, Stallmach A, Claus RA, Bruns T (2015) Imbalance of von Willebrand factor and its cleaving protease ADAMTS13 during systemic inflammation superimposed on advanced cirrhosis. Liver Int 35: 37-45.


Ermolaeva, Maria

Ermolaeva MA, Segref A, Dakhovnik A, Ou HL, Schneider JI, Utermöhlen O, Hoppe T, Schumacher B. (2013) DNA damage in germ cells induces an innate immune response that triggers systemic stress resistance. Nature 501: 416-420.


Frahm, Christiane

Sieber MW, Guenther M, Jaenisch N, Albrecht-Eckardt D, Kohl M, Witte OW, Frahm C (2014) Age-specific transcriptional response to stroke. Neurobiol Aging 35: 1744-1754.

Jaenisch N, Popp A, Guenther M, Schnabel J, Witte OW, Frahm C (2014) Pro-apoptotic function of GABA-related transcripts following stroke. Neurobiol Dis 70: 237-244.


Gräler, Markus

Reimann CM, Thuy AV, Weigel C, Gräler MH (2015) Sphingosine 1-phosphate (S1P) in cancer immunity and development. Transl Cancer Res doi: 10.3978/j.issn.2218-676X.2015.09.01 in press

Vettorazzi S, Bode C, Dejager L, Frappart L, Shelest E, Klassen C, Tasdogan A, Reichardt HM, Libert C, Schneider M, Weih F, Henriette Uhlenhaut N, David JP, Gräler MH, Kleiman A, Tuckermann JP (2015) Glucocorticoids limit acute lung inflammation in concert with inflammatory stimuli by induction of SphK1. Nat Commun 6: 7796.

Nussbaum C, Bannenberg S, Keul P, Gräler MH, Goncalves-de-Albuquerque CF, Korhonen H, von Wnuck Lipinski K, Heusch G, de Castro Faria Neto HC, Rohwedder I, Gothert JR, Prasad VP, Haufe G, Lange-Sperandio B, Offermanns S, Sperandio M, Levkau B (2015) Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin. Nat Commun 6: 6416.

Karaca I, Tamboli IY, Glebov K, Richter J, Fell LH, Grimm MO, Haupenthal VJ, Hartmann T, Gräler MH, van Echten-Deckert G, Walter J (2014) Deficiency of sphingosine-1-phosphate lyase impairs lysosomal metabolism of the amyloid precursor protein. J Biol Chem 289: 16761-16772.

Thuy AV, Reimann CM, Hemdan NY, Gräler MH (2014) Sphingosine 1-phosphate in blood: function, metabolism, and fate. Cell Physiol Biochem 34: 158-171.

Bode C, Berlin M, Röstel F, Teichmann B, Gräler MH (2014) Evaluating sphingosine and its analogues as potential alternatives for aggressive lymphoma treatment. Cell Physiol Biochem 34: 1686-1700.

Vogt K, Mahajan-Thakur S, Wolf R, Bröderdorf S, Vogel C, Böhm A, Ritter CA, Gräler M, Oswald S, Greinacher A, Kroemer HK, Jedlitschky G, Rauch BH (2018). "Release of

Platelet-Derived Sphingosine-1-Phosphate Involves Multidrug Resistance Protein 4 (MRP4/ABCC4) and Is Inhibited by Statins." Thromb Haemost. 2018 Jan;118(1):132-142.

 

Weske S, Vaidya M, Reese A, von Wnuck Lipinski K, Keul P, BayerJK, Fischer JW, Flögel U, Nelsen J, Epple M, Scatena M, Schwedhelm E, Dörr M, Völzke H, Moritz E,

Hannemann A, Rauch BH, Gräler MH, Heusch G and Levkau B (2018). "Targeting sphingosine-1-phosphate lyase as an anabolic therapy for bone loss" Nat Med. accepted.

 

Chung, H. Y., A. S. Kollmey, A. Schrepper, M. Kohl, M. F. Blass, S. N. Stehr, A. Lupp, M. H. Gräler and R. A. Claus (2017). "Adjustment of Dysregulated Ceramide Metabolism

in a Murine Model of Sepsis-Induced Cardiac Dysfunction." Int J Mol Sci 18(4).


Chung, H. Y., C. J. Witt, N. Jbeily, J. Hurtado-Oliveros, B. Giszas, A. Lupp, M. H. Gräler, T. Bruns, A. Stallmach, F. A. Gonnert and R. A. Claus (2017). "Acid Sphingomyelinase

Inhibition Prevents Development of Sepsis Sequelae in the Murine Liver." Sci Rep 7(1): 12348.


Mitroi, D. N., I. Karunakaran, M. Gräler, J. D. Saba, D. Ehninger, M. D. Ledesma and G. van Echten-Deckert (2017). "SGPL1 (sphingosine phosphate lyase 1) modulates

neuronal autophagy via phosphatidylethanolamine production." Autophagy 13(5): 885-899.


Polzin, A., K. Piayda, P. Keul, L. Dannenberg, A. Mohring, M. Gräler, T. Zeus, M. Kelm and B. Levkau (2017). "Plasma sphingosine-1-phosphate concentrations are associated

with systolic heart failure in patients with ischemic heart disease." J Mol Cell Cardiol 110: 35-37.


von Wnuck Lipinski, K., S. Weske, P. Keul, S. Peters, H. A. Baba, G. Heusch, M. H. Gräler and B. Levkau (2017). "Hepatocyte nuclear factor 1A deficiency causes hemolytic

anemia in mice by altering erythrocyte sphingolipid homeostasis." Blood 130(25): 2786-2798.


Weis, S., I. Rubio, K. Ludwig, C. Weigel and E. Jentho (2017). "Hormesis and Defense of Infectious Disease." Int J Mol Sci 18(6).

Winkler, M. S., A. Nierhaus, A. Poppe, G. Greiwe, M. H. Gräler and G. Daum (2017). "Sphingosine-1-Phosphate: A Potential Biomarker and Therapeutic Target for Endothelial
Dysfunction and Sepsis?" Shock 47(6): 666-672.

Hemdan, N. Y., Weigel, C., Reimann, C. M., Gräler, M. H. (2016) Modulating sphingosine 1-phosphate signaling with DOP or FTY720 alleviates vascular and immune defects in mouse sepsis. European Journal of Immunology 46, 2767-2777

Chung, H. Y., D. C. Hupe, G. P. Otto, M. Sprenger, A. C. Bunck, M. J. Dorer, C. L. Bockmeyer, H. P. Deigner, M. H. Gräler, and R. A. Claus (2016) Acid sphingomyelinase promotes endothelial stress response in systemic inflammation and sepsis. Molecular Medicine 22 412-423


Heinemann, Stefan H.

Schink M, Leipold E, Schirmeyer J, Schönherr R, Hoshi T, Heinemann SH (2015) Reactive species modify NaV1.8 channels and affect action potentials in murine dorsal root ganglia neurons. Pflugers Arch EJP (in press)

Sahoo N, Hoshi T, Heinemann SH (2014) Oxidative modulation of voltage-gated potassium channels. Antioxid Redox Signal 21: 933-952.

Ojha NK, Nematian-Ardestani E, Neugebauer S, Borowski B, El-Hussein A, Hoshi T, Leipold E, Heinemann SH (2014) Sodium channels as gateable non-photonic sensors for membrane-delimited reactive species. Biochim Biophys Acta 1838: 1412-1419.

Heinemann SH, Hoshi T, Westerhausen M, Schiller A (2014) Carbon monoxide - physiology, detection and controlled release. Chem Commun (Camb) 50: 3644-3660.

Sahoo N, Goradia N, Ohlenschläger O, Schönherr R, Friedrich M, Plass W, Kappl R, Hoshi T, Heinemann SH (2013) Heme impairs the ball-and-chain inactivation of potassium channels. Proc Natl Acad Sci U S A 110: E4036-4044.


Heinzel, Thorsten

Balakrishnan P, Liebe T, Amro E, Dhaka L, Heinzel T, Heller R (2018) Metabolic stress - signaling and metabolic adaptation. The Science of Hormesis in Health and Longevity, accepted.

Marx C, Marx-Blümel L, Thierbach R, Poburski D, Becker S, Wittig S, Lehmann R, Slevogt H, Heinzel T, Wang ZQ, Beck JF, Sonnemann J (2017) The sirtuin 1/2 inhibitor tenovin-1 induces a nonlinear apoptosis-inducing factor-dependent cell death in a p53 null Ewing's sarcoma cell line. Investigational New Drugs, Epub ahead of print, doi:10.1007/s10637-017-0541-1.

Wieczorek M, Gührs KH, and Heinzel T (2017) Assessment of HDACi-induced acetylation of nonhistone proteins by mass spectrometry. Methods in Molecular Biology 1510, 313-327.

Schäfer C, Göder A, Beyer M, Kiweler N, Mahendrarajah N, Rauch A, Nikolova T, Stojanovic N, Wieczorek M, Reich T, Tomicic MT, Linnebacher M, Sonnemann J, Dietrich S, Sellmer A, Mahboobi S, Heinzel T, Schneider G, and Krämer OH (2017) Class I histone deacetylases regulate p53/NF-kB crosstalk in cancer cells. Cellular Signalling 29, 218-225.

Wagner T, Kiweler N, Wolff K, Knauer SK, Brandl A, Hemmerich P, Dannenberg JH, Heinzel T, Schneider G, Krämer OH (2015) Sumoylation of HDAC2 promotes NF-κB-dependent gene expression. Oncotarget 6: 7123-7135.

Rauch A, Hennig D, Schäfer C, Wirth M, Marx C, Heinzel T, Schneider G, Krämer OH (2014) Survivin and YM155: How faithful is the liaison? Biochim Biophys Acta Rev Canc 1845: 202-220.

Licht V, Noack K, Schlott B, Förster M, Schlenker Y, Licht A, Krämer OH, Heinzel T (2014) Caspase-3 and Caspase-6 cleave STAT1 in leukemic cells. Oncotarget 5: 2305-2317.

Ginter T, Fahrer J, Kröhnert U, Fetz V, Garrone A, Stauber RH, Reichardt W, Müller-Newen G, Kosan C, Heinzel T, Krämer OH (2014) Arginine residues within the DNA binding domain of STAT3 promote intracellular shuttling and phosphorylation of STAT3. Cell Signal 26: 1698-1706.

Ginter T, Bier C, Knauer SK, Sughra K, Hildebrand D, Münz T, Liebe T, Heller R, Henke A, Stauber RH, Reichardt W, Schmid JA, Kubatzky KF, Heinzel T, Krämer OH (2012) Histone deacetylase inhibitors block IFNγ-induced STAT1 phosphorylation. Cell Signal 24: 1453-1460.


Heller, Regine

Große C, Bergner N, Dellith J, Heller R, Bauer M, Mellmann A, Popp J, Neugebauer U (2015) Label-free imaging and spectroscopic analysis of intracellular bacterial infections. Anal Chem 87: 2137-2142.

Skorokhod OA, Barrera V, Heller R, Carta F, Turrini F, Arese P, Schwarzer E (2014) Malarial pigment hemozoin impairs chemotactic motility and transendothelial migration of monocytes via 4-hydroxynonenal. Free Radic Biol Med 75: 210-221.


Hübner, Christian

Khaminets A*, Heinrich T*, Mari M, Grumati P, Huebner AK, Akutsu M, Liebmann L, Stolz A, Nietzsche S, Koch N, Mauthe M, Katona I, Qualmann B, Weis J, Reggiori F, Kurth I§, Hübner CA§, Dikic I§ (2015) Regulation of endoplasmic reticulum turnover by selective autophagy. Nature 522: 354-358.    *equal contribution and §shared senior authorship

Leipold E, Liebmann L, Korenke GC, Heinrich T, Giesselmann S, Baets J, Ebbinghaus M, Goral RO, Stödberg T, Hennings JC, Bergmann M, Altmüller J, Thiele H, Wetzel A, Nürnberg P, Timmerman V, De Jonghe P, Blum R, Schaible HG, Weis J, Heinemann SH, Hübner CA, Kurth I (2013) A de novo gain-of-function mutation in SCN11A causes loss of pain perception. Nature Genet 45: 1399-1404.


Koeberle, Andreas

Koeberle A, Pergola C, Shindou H, Koeberle SC, Shimizu T., Laufer SA, Werz O (2015) Role of p38 mitogen-activated protein kinase in linking stearoyl-CoA desaturase-1 activity with ER homeostasis. FASEB J 29: 2439-2449.

Koeberle A, Löser K, Thürmer M (2016) Stearoyl-CoA desaturase-1 and adaptive stress signaling. BBA-MOL CELL BIOL L 1861: 1719-1726.

Pein H, Koeberle SC, Voelkel M, Schneider F, Rossi A, Thürmer M, Löser K, Sautebin L, Morrison H, Werz O, Koeberle A (2017) Vitamin A regulates Akt signaling through the phospholipid fatty acid composition. FASEB J 31: 4566-4577

Glatzel, D.K., Koeberle, A., Pein, H., Loeser, K., Stark, A., Keksel, N., Werz, O., Müller, R., Bischoff, I., Fürst, R. (2018) Acetyl-CoA carboxylase 1 regulates endothelial cell migration by shifting the phospholipid composition J Lipid Res 59: 298-311

 

Kosan, Christian

Kosan C, Rashkovan M, Ross J, Schaffer A, Saba I, Lemsaddek W, Trudel M, Möröy# T (2014) The transcription factor Miz-1 is required for embryonic and stress-induced erythropoiesis but dispensable for adult erythropoiesis. Am J Blood Res 4: 7-19. #co-corresponding author


Lorkowski, Stefan

Wallert M, Schmölz L, Koeberle A, Krauth V, Glei M, Galli F, Werz O, Birringer M, Lorkowski S (2015) α-Tocopherol long-chain metabolite α-13'-COOH affects the inflammatory response of lipopolysaccharide-activated murine RAW264.7 macrophages. Mol Nutr Food Res 59: 1524-1534.

Ciffolilli S, Wallert M, Krauth V, Werz O, Bartolini D, Piroddi M, Sebastiani B, Lorkowski* S, Birringer* M, Galli* G (2015) Human serum determination and in vitro anti-inflammatory activity of vitamin E α-(13'-hydroxy)-6-hydroxychroman metabolite. Free Radic Biol Med, in press. *These authors contributed equally.

Wallert M, Mosig S, Rennert K, Funke H, Ristow M, Pellegrino RM, Cruciani G, Galli F, Lorkowski S, Birringer M (2014) Long-chain metabolites of α-tocopherol occur in human serum and inhibit macrophage foam cell formation in vitro. Free Radic Biol Med 68: 43-51.

Wallert M, Schmölz L, Galli F, Birringer M, Lorkowski S (2014) Regulatory metabolites of vitamin E and their putative relevance for atherogenesis. Redox Biol 2: 495-503.


Morrison, Helen

Riecken LB, Tawamie H, Dornblut C, Buchert R, Ismayel A, Schulz A, Schumacher J, Sticht H, Pohl KJ, Cui Y, Reis A, Morrison* H, Jamra* RA (2015) Inhibition of RAS Activation Due to a Homozygous Ezrin Variant in Patients with Profound Intellectual Disability. Hum Mutat 36: 270-278. (* shared senior authorship).

Schulz* A, Kyselyova* A, Baader SL, Jung MJ, Zoch A, Mautner VF, Hagel* C, Morrison* H (2014) Neuronal merlin influences ERBB2 receptor expression on Schwann cells through neuregulin 1 type III signalling. Brain 137: 420-432.  * shared first and senior authorships

Schulz A, Baader SL, Niwa-Kawakita M, Jung MJ, Bauer R, Garcia C, Zoch A, Schacke S, Hagel C, Mautner VF, Hanemann CO, Dun XP, Parkinson DB, Weis J, Schröder JM, Gutmann DH, Giovannini M, Morrison H (2013) Merlin isoform 2 in neurofibromatosis type 2-associated polyneuropathy. Nat Neurosci 16: 426-433.

Geißler KJ, Jung MJ, Riecken LB, Sperka T, Cui Y, Schacke S, Merkel U, Markwart R, Rubio I, Than ME, Than-Breithaupt C, Peuker S, Seifert R, Kaupp UB, Herrlich P, Morrison H (2013) Regulation of Son of sevenless by the membrane-actin linker protein ezrin. Proc Natl Acad Sci USA 110: 20587-20592.


Qualmann, Britta

Hou W, Izadi M, Nemitz S, Haag N, Kessels MM, Qualmann B (2015) The actin nucleator Cobl is controlled by calcium and calmodulin. PLoS Biol 13: e1002233.

Schneider K, Seemann E, Liebmann L, Ahuja R, Koch D, Westermann M, Hübner CA, Kessels MM§, Qualmann B§ (2014). ProSAP1 and membrane nanodomain-associated syndapin I promote postsynapse formation and function. J Cell Biol 205: 197-215. 
§shared senior authorship

Baple E*, Maroofian R*, Chioza BA*, Izadi M*, Cross HE, Al-Turki S, Barwick K, Wagner K, Coblentz R, Zainy T, Patton MA, Qualmann B, Hurles M, Kessels MM, Crosby AH. (2014) Mutations in KPTN cause macrocephaly, neurodevelopmental delay, and seizures. Am J Hum Genet 94(1):87-94.       *shared authorships

Schüler S, Hauptmann J, Perner B, Kessels MM, Englert C, Qualmann B (2013). Ciliated sensory hair cell formation and function require the F-BAR protein syndapin I and the WH2 domain-based actin nucleator Cobl. J Cell Sci 126: 196-208.

Nolze A, Schneider J, Keil R, Lederer M, Huttelmaier S, Kessels MM, Qualmann B, Hatzfeld M (2013) FMRP regulates actin filament organization via the armadillo protein p0071. RNA 19: 1483-1496.


Ristow, Michael

Weimer S, Priebs J, Kuhlow D, Groth M, Priebe S, Mansfeld J, Merry TL, Dubuis S, Laube B, Pfeiffer AF, Schulz TJ, Guthke R, Platzer M, Zamboni N, Zarse K, Ristow M (2014) D-Glucosamine supplementation extends lifespan of nematodes and of aging mice. Nature Communications 5: 3563.

Segref A, Kevei E, Pokrzywa W, Schmeisser K, Mansfeld J, Livnat-Levanon N, Ensenauer R, Glickman MH, Ristow M, Hoppe T (2014) Mitochondrial stress evokes reduced activity of the ubiquitin/proteasome system modulating pathogenesis of human metabolic diseases. Cell Metabolism 19: 642-52.

Schmeisser K*, Mansfeld J*, Kuhlow D, Weimer S, Priebe S, Heiland I, Birringer M, Groth M, Segref A, Kanfi Y, Price NL, Schmeisser S, Schuster S, Pfeiffer AFH, Guthke R, Platzer M, Hoppe T, Cohen HY, Zarse K, Sinclair DA, Ristow M (2013) Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide. Nature Chemical Biology 9: 693-700 - *shared first authorship


Rubio Ignacio

Wetzker R, Rubio I (2012) Hormetic signalling patterns. Dose Response 10: 83-90

Weis S, Rubio I, Ludwig K, Weigel C, Jentho E. Hormesis and Defense of Infectious Disease. Int J Mol Sci. 2017;18(6).

Gottlieb-Abraham E, Gutman O, Pai GM, Rubio I, Henis YI. The residue at position 5 of the N-terminal region of Src and Fyn modulates their myristoylation, palmitoylation, and membrane interactions. Mol Biol Cell. 2016;27(24):3926-36.

Pai GM, Zielinski A, Koalick D, Ludwig K, Wang Z-Q, Borgmann K, Pospiech H, Rubio I. TSC loss distorts DNA replication programme and sensitises cells to genotoxic stress. Oncotarget. 2016;7(51):85365-80


Rudolph, K. Lennard

Behrens A*, van Deursen JM*, Rudolph KL*, Schumacher B* (2014) Impact of genomic damage and ageing on stem cell function. Nat Cell Biol 16: 201-207. *co-correspondence


Schuster, Stefan

Stark H, Fichtner M, König R, Lorkowski S, Schuster S (2015). Causes of upregulation of glycolysis in lymphocytes upon stimulation. A comparison with other cell types. Biochimie doi: 10.1016/j.biochi.2015.09.017

Schuster S, Boley D, Möller P, Stark H, Kaleta C (2015) Mathematical models for explaining the Warburg effect: A review focussed on ATP and biomass production. Biochem Soc Trans doi: 10.1016/j.biochi.2015.09.017.

Schuster S, Boley D, Möller P, Kaleta C (2015a) A minimal model for explaining the higher ATP production in the Warburg effect. Proceed. GCB 2015, PeerJ PrePrints 3: e1609.


Wang, Zhao-Qi

Bruhn C, Zhou ZW, Ai H, Wang ZQ (2014) The essential function of the MRN complex in the resolution of endogenous replication intermediates. Cell Rep 6: 182-195.

Min WK, Bruhn C, Grigaravicius P, Zhou ZW, Li F, Krüger A, Siddeek B, Greulich KO, Popp O, Meisezahl C, Calkhoven C, Bürkle A, Xu X, Wang ZQ (2013) Poly(ADP-ribose) binding to Chk1 at stalled replication forks is required for S-phase checkpoint activation. Nat Commun 4: 2993.


Werz, Oliver

Gerstmeier J, Weinigel C, Rummler S, Rådmark O, Werz O, Garscha U (2015) Time-resolved in situ assembly of the leukotriene-synthetic 5-LO / FLAP complex in blood leukocytes. FASEB J in press.


Wetzker, Reinhard

Madishetti S, Schneble N, König C, Hirsch E, Schulz S, Müller JP, Wetzker R (2014) PI3Ky integrates cAMP and Akt signalling of the μ-opioid receptor. Br J Pharmacol 171: 3328-3337.

Schmidt C, Schneble N, Wetzker R (2014) The fifth dimension of innate immunity. J Cell Commun Signal 8: 363-367.

Perino A, Beretta M, Kilić A, Ghigo A, Carnevale D, Repetto IE, Braccini L, Longo D, Liebig-Gonglach M, Zaglia T, Iacobucci R, Mongillo M, Wetzker R, Bauer M, Aime S, Vercelli A, Lembo G, Pfeifer A, Hirsch E (2014) Combined inhibition of PI3Kβ and PI3Ky reduces fat mass by enhancing α-MSH-dependent sympathetic drive. Sci Signal 7: ra110.

Schmidt C, Schneble N, Müller JP, Bauer R, Perino A, Marone R, Rybalkin SD, Wymann MP, Hirsch E, Wetzker R (2013) Phosphoinositide 3-kinase γ mediates microglial phagocytosis via lipid kinase-independent control of cAMP. Neuroscience 233: 44-53.

Recknagel P, Gonnert FA, Westermann M, Lambeck S, Lupp A, Rudiger A, Dyson A, Carré JE, Kortgen A, Krafft C, Popp J, Sponholz C, Fuhrmann V, Hilger I, Claus RA, Riedemann NC, Wetzker R, Singer M, Trauner M, Bauer M (2012) Liver dysfunction and phosphatidylinositol-3-kinase signalling in early sepsis: experimental studies in rodent models of peritonitis. PLoS Med 9:e1001338.


Witte, Otto W.

Schumacher L*, Urbach A*, Lutzenburg M, Bidmon HJ, Witte OW (2014) Bihemispheric ischemic tolerance induced by a unilateral focal cortical lesion. Brain Res 1570: 54-60.  *shared first authorship